Techniques for improving the specificity of sandwich enzyme‐linked immunosorbent assay‐based drug screening
ELISA kits can be modified to improve assay specificity. These techniques allow false-positive results to be excluded, reducing the number…
Elucidating important factors and corresponding method optimization for sensitive detection of small peptide drugs in human urine by solid‐phase extraction and UPLC‐HRMS: The influence of MS scan modes, protein precipitants, and ammonium formate
Several important factors for sensitive detection of small peptide drugs in human urine by SPE and UPLC-HRMS were investigated. The…
Doping control of estra‐4,9‐diene‐3,17‐dione in horses
This paper describes the doping control of dienedione in horses. An in vivo metabolism study and the elimination of dienedione…
Doping control analysis of myo‐inositol trispyrophosphate and 10 bisphosphonates in equine plasma by ion chromatography–mass spectrometry and its application to clodronic acid horse administration
Bisphosphonates and myo-inositol trispyrophosphate (ITPP) are two classes of difficult-to-detect polar drugs that are prohibited under the rules of racing.…
Analytical and behavioral characterization of 1‐hexanoyl‐LSD (1H‐LSD)
Analytical and pharmacological data were obtained from 1-hexanoyl-LSD (1H-LSD). The mouse head-twitch response revealed that 1H-LSD induced LSD-like effects (ED50 = 387 nmol/kg).…
The effect of incidental ethanol exposures on the formation of blood phosphatidylethanol
Accumulating evidence and international consensus support a 20 μg/L phosphatidylethanol (PEth) cutoff to distinguish abstinence from ethanol consumption. Little research…
Acute atrazine intoxication in heifers: Case report and toxicological studies
We report a spontaneous case of atrazine acute intoxication cattle exposed at a beef farm in Argentina. High levels of…
Confirmation of ethanol administration in racing greyhounds by LC‐MS‐MS
Ethanol causes depression of the central nervous system and its use in professional animal racing must be controlled due to…
Synthesis and analytical characterization of 1‐(2‐thienoyl)‐6‐allyl‐nor‐d‐lysergic acid diethylamide (1T‐AL‐LAD)
Abstract Lysergic acid diethylamide (LSD) analogs have emerged as new psychoactive substances (NPS) since the mid-2010s, and new compounds continue…
In vitro activation of the CB1 receptor by the semi‐synthetic cannabinoids hexahydrocannabinol (HHC), hexahydrocannabinol acetate (HHC‐O) and hexahydrocannabiphorol (HHC‐P)
The semi-synthetic cannabinoids market is developing rapidly, and 24 European countries have identified HHC, often sold openly. This study characterized…