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Detection of the selective androgen receptor modulator S‐23 and its metabolites in equine urine and plasma following oral administration

S-23, an arylpropionamide selective androgen receptor modulator, presents a significant threat to sports doping. An equine oral administration showed that…

Detection of transgenes in equine dried blood spots using digital PCR and qPCR for gene doping control

DNA extraction methods for dried blood spots (DBS) were evaluated to determine the suitability of the use of DBS as…

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Analytical advances in horseracing medication and doping control from 2018 to 2023

Analytical advances in equine medication and doping control from 2018 to 2023 are presented. Major trends in publications are summarised…

The detection of ACTH and insulin in equine plasma by solid‐phase extraction and micro‐flow LC/MSMS

Adrenocorticotropic hormone (ACTH) and insulin variants were detected in equine plasma using a high-throughput LC/MSMS assay incorporating SPE, peptide derivatisation…

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In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers…

Generic Drug User Fee Amendments

FDA is soliciting general comments on GDUFA II Program Fee: List of Abbreviated New Drug Application Sponsors and Application Numbers.…

Transcriptomic Biomarkers in Blood Indicative of the Administration of Recombinant Human Erythropoietin to Thoroughbred Horses

RNA-sequencing of equine whole blood identified biomarkers linked to recombinant human erythropoietin (rhEPO)-induced erythropoiesis in thoroughbred horses. ABSTRACT Erythropoiesis-stimulating agents…

POSTPONED – Interested Parties Meeting: Implementation of the Best Pharmaceuticals for Children Act and Pediatric Research Equity Act – 05/15/2025

Section 508 of PL 112-144 (FDASIA) requires FDA to obtain recommendations and relevant information from interested parties on the required…