New Transcriptomic Biomarkers for Detection of the Recombinant Human Erythropoietin (rHuEPO) MirCERA in Horses
ALAS2, CA1, and SLC4A1 mRNAs have previously been described as blood doping biomarkers in humans. A qPCR method was developed…
Skeletal Muscle Memory: An Update From the Antidoping Perspective
ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention…
Equine Doping Controls of Thymosin β$$ beta $$4: A Population Study and Strategy for Misuse Detection
First estimation of the endogenous TB4 concentration in racing horses’ blood samples was performed through a population study. Detection of…
959: Is there a benefit from switching to dexmedetomidine when sedation is started with midazolam?
Show notes at pharmacyjoe.com/episode959. In this episode, I’ll discuss whether there is a benefit from switching to dexmedetomidine when sedation…
Discovery of Biomarkers of a Recombinant Human Erythropoietin Administration to Thoroughbred Geldings by Label‐Free Proteomics
Label-free proteomics was used to discover plasma protein biomarkers in Thoroughbred geldings after administration with a recombinant human erythropoietin (rhEPO)…
High‐Throughput Equine Doping Controls on a Trapped Ion Mobility Quadrupole‐Time‐of‐Flight Mass Spectrometer: Technical Considerations of dia/slice/prmPASEF Applied to the Long‐Term Detection of Monoclonal Antibodies
Evaluation of three data acquisition strategies named diaPASEF, slicePASEF, and prmPASEF on a trapped ion mobility spectrometry quadrupole-time-of-flight (TIMS-Q-TOF) mass…
Pharmacokinetics of Two Formulations of Altrenogest Administered to Mares
Pharmacokinetics of altrenogest in mares to determine expected concentrations of plasma altrenogest associated with oral and intramuscular administration. Quantification of…
Suitability of Hair Testing in Medical Dispensing Errors: A Fatal Case of Gliclazide Poisoning
ABSTRACT A patient was prescribed a new treatment, 40 mg furosemide. Her pharmacist mistakenly dispensed 40 mg gliclazide instead. After 3 weeks…
Emerging Human Medications in Racing Animals: Analytical and Regulatory Challenges
A simple extraction followed by an LC-MS/MS method is presented to effectively screen for pregabalin and metformin, in addition to…
Doping Control Analysis of Perfluorocarbons in Equine Plasma by Headspace Gas Chromatography‐Tandem Mass Spectrometry
In order to control the potential misuse of perfluorocarbons as an oxygen carrier in equine sports, a simple and sensitive…