Estimating human pharmacokinetic parameters for electronic nicotine delivery system products from chemical analyses of their aerosols

The nicotine concentration in the e-liquid of an electronic nicotine delivery system has proved to be a poor predictor of…

Human metabolism of the semi‐synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples

Metabolism of HHC was elucidated in human hepatocytes and urine samples. Metabolites were extensively glucuronidated in non-hydrolysed urine samples. 11-OH-HHC…

Preclinical pharmacokinetic studies of villocarine A, an active Uncaria alkaloid

The pharmacokinetic properties of villocarine A have been determined in a series of in vitro and in vivo studies. Villocarine…

Stability of carboxy‐hemoglobin during storage at different temperatures

Today, CO rebreathing is used almost exclusively to determine hemoglobin mass and blood volume. A limiting factor is the presence…

Investigative testing of miscellaneous materials

Drug Testing and Analysis, Volume 17, Issue 3, Page 420-426, March 2025.

Identification of N‐pyrrolidino protonitazene in powders sold as heroin and associated with overdose clusters in Dublin and Cork, Ireland

N-Pyrrolidino protonitazene was found in samples sold as heroin in Dublin and Cork, Ireland, in late 2023. These were associated…

Is blood blood? Comparing quantitation of endogenous steroids and luteinizing hormone in concurrently collected venous serum and Tasso+ SST capillary serum samples

Twenty individuals donated venous and capillary serum weekly for 5-6 weeks. Agreement between capillary and venous serum for T, T/A4,…

LC–MS/MS quantification of olanzapine in hair after alkaline digestion

This graphical abstract illustrates every step of the laboratory work in this manuscript. Sample collection, segmentation, and alkaline digestion of…

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The influence of cosmetic treatments in the uptake of in vitro cocaine contamination in hair

This study investigated how common cosmetic treatments (bleach, henna, gel, and dry shampoo) impact cocaine and benzoylecgonine (BE) concentrations in…