This study showcases QuickProbe GC–MS as a powerful tool for identifying fentanyl and buprenorphine in transdermal patches. Our in situ extraction technique prevents column overload and carryover while delivering results in under 2 min. The method successfully detects low concentrations of opioids in patches with the selectivity required for forensic identification. This approach enhances investigations through improved laboratory safety and significantly reduced analysis time, offering potential applications for emerging drugs of abuse.

ABSTRACT

The use of transdermal patches, primarily for pain relief, has grown significantly in recent years. This increase in legitimate use has been accompanied by a rise in their illegal use. Consequently, forensic laboratories are facing a growing number of these complex samples requiring analysis. These systems often involve complex sample matrices, demanding analytical techniques that are both efficient and highly sensitive. This study introduces the application of QuickProbe GC–MS for the rapid identification of fentanyl and buprenorphine in transdermal patches. Utilizing in situ extraction, the method eliminates the need for time-consuming sample preparation, achieving a full analysis cycle time of under 2 min. QP GC–MS successfully detected fentanyl and buprenorphine at concentrations as low as 4.125 and 5 mg, respectively, while adhering to the highest selectivity guidelines. This rapid and streamlined approach has broader implications for forensic investigations, enabling high-throughput screening of seized drug samples and potentially extending to the analysis of emerging drugs of abuse. The speed and efficiency of QP GC–MS make it a valuable tool for law enforcement, public health agencies, and toxicology labs facing the challenge of keeping pace with evolving drug trends.