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Why the racing industry and equestrian disciplines need to implement population pharmacokinetics: To learn, explain, summarize, harmonize, and individualize

Population pharmacokinetics (POP PK) is a pharmacokinetic tool, which measures and explains the variability in drug exposure and drug effect…

Urinary metabolites indicative of the administration of hypoxen monitored by liquid chromatography–high resolution/accurate mass tandem mass spectrometry

First data on suitable urinary markers indicative of the administration of the poly(dihydroxyphenylene) thiosulfonate-based drug hypoxen were generated, which can…

Methylation of phase II metabolites of endogenous anabolic androgenic steroids to improve analytical performance

Intact phase II metabolites of endogenous anabolic androgenic steroids give important information about metabolism and have the potential to improve…

Individual identification method using samples associated with doping tests: A comparison of mitochondrial and nuclear genetic data

DNA analysis is used to detect attempts at manipulating or substituting samples during doping control. To determine a suitable method,…

Metabolism of highly potent synthetic opioid nitazene analogs: N‐ethyl‐N‐(1‐glucuronyloxyethyl) metabolite formation and degradation to N‐desethyl metabolites during enzymatic hydrolysis

This study revealed that nitazene analogs were mainly metabolized by N-1-hydroxylation followed by glucuronidation, N-deethylation, O-dealkylation followed by glucuronidation, and…

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Is there a relationship between abuse of alcohol and illicit drugs seen in hair results?

Abstract Combined use of alcohol and illicit drugs is a serious health and social problem. In this study, it was…

Trends in exposure to drugs and prohibited substances among sports: A nationwide analysis of 2008–2022 inquiry records

The study collected over 30,000 data points from three major national anti-doping inquiry systems spanning from 2008 to 2022. Approximately…

Development of a method to evaluate the effects of external environments on drug stability in nails using micro‐segmental analysis

An evaluation method using micro-segmental analysis (MSA) of a single nail was developed to examine the effects of external environments…

Development of 3β,4α‐dihydroxy‐5α‐androstan‐17‐one standard solution for doping analyses

In this work, a certified reference material (CRM) for 3β,4α-dihydroxy-5α-androstan-17-one (DHAS), a metabolite of formestane that is used to conceal…